Bitesize Bio

Development of ultrasensitive immunoassays for SARS-CoV-2 antibody detection

January 30, 2023
In this webinar, you will learn about the:
Importance of assay sensitivity in COVID-19 serology research;
Benefits of Single Molecule Counting (SMC™) ultrasensitive immunoassay technology;
Development of the MilliporeSigma SMC™ SARS-CoV-2 kits.
Immunoassay-based serology techniques play key roles in many SARS-CoV-2 research programs due to their ability to identify and characterize the immune response of individuals already infected by the virus through analysis of biomarkers such as immunoglobulins.

However, the limited sensitivity and resolution offered by traditional assay platforms and their serology assays can leave crucial research questions unanswered.

We harnessed the power of the SMC™ ultrasensitive immunoassay platform to develop SARS-CoV-2-specific antibody assays, which can be used to resolve subtle differences in humoral immunity among individuals and detect antibody response earlier after infection. These assays may also be used to thoroughly profile immune responses after vaccine challenge.

This webinar describes how these new kits were developed by the Custom Assay & Sample Testing (CAST) team at MilliporeSigma, and details the key data from the assay development and verification work, including signal linearity, sensitivity and specificity determination, assay precision, and cross-reactivity.

Products presented in this webinar are For Research Use Only. Not For Use In Diagnostic Procedures.